Ramos GP, et al. - The safety and outcomes of endoscopy for overt gastrointestinal bleeding (GIB) were evaluated in the setting of severe thrombocytopenia in liver cirrhosis (LC) and non-liver cirrhosis (NLC). In the setting of severe thrombocytopenia in both LC and NLC patients, endoscopy for overt GIB appeared safe, it had moderate diagnostic and therapeutic yields with high initial hemostasis rate. Endoscopy was also correlated with a significant decrease in packed red blood cell (pRBC) and platelet transfusions. Recurrent bleeding and all-cause mortality rates remained high.