Sanjoy SS, Choi YH, Sparrow RT, et al. - Higher rates of in‐hospital major adverse events (MAE) after left atrial appendage closure were found in patients ≥80 years old vs those aged <80 years old (6.0% vs 4.6%). Factors related to in‐hospital MAE among both groups were: female gender and the presence of heart failure, diabetes, renal disease, and anemia.

• Using the National Inpatient Sample, 6779 hospitalizations for left atrial appendage closure were included; 2371 (35%) were ≥80 years old and 4408 (65%) were <80 years old.

• In‐hospital MAE was defined as the composite of postprocedural bleeding, vascular and cardiac complications, acute kidney injury, stroke, and death.

• A numerically higher rate of cardiac complications and death was found in patients ≥80 years old.

• Odds of in‐hospital MAE in patients ≥80 years old were found to be higher in those with female gender (1.61‐fold), preprocedural congestive heart failure (≈2‐fold), diabetes (≈1.5‐fold), renal disease (≈2.6‐fold), anemia (≈2.7‐fold), and dementia (≈5‐fold).

• A higher risk of in‐hospital MAE, in patients <80 years old, was evident in women (≈1.4‐fold) and those with diabetes (≈1.3‐fold), renal disease (≈2.6‐fold), anemia (≈2‐fold), and dyslipidemia (≈1.2‐fold).