Bandhan IH, Ahmad HI, Ahmedullah AK, et al. - Low-dose prednisolone regimen may effectively treat lupus nephritis (LN).

• In this open-label randomized clinical trial, 32 LN patients were randomized into low-dose (experimental) and high-dose (control) groups; oral prednisolone, 0.5 mg/kg/d and 1 mg/kg/d were administered to experimental and control groups respectively for initially 4 weeks then tapered.

• In each group, 66.7% of patients had complete renal remission, and renal remission (partial/complete) was achieved in 86.7% of those in the prednisolone low-dose group and 83.3% in the high-dose group.

• In the prednisolone low-dose group, lower were steroid dose-related side effects and rate of infections.