Corazzi V, Ciorba A, Bianchini C, et al. - In this retrospective case-control study, researchers described the outcome of cochlear implantation in children affected by severe-to-profound sensorineural hearing loss, due to symptomatic or asymptomatic congenital cytomegalovirus (cCMV) infection, especially comparing their performance results to that of matched mutated Connexin 26 (Cx26) implanted patients. Compared with the asymptomatic cCMV and Cx26 mutation groups, the data indicate that children affected by cCMV have improved language abilities over time, although the symptomatic cCMV group reached a lower language stage 3–4 years after CI. However, to date, speech therapy-supported CI may be considered a successful intervention for children affected by cCMV-related severe-to-profound hearing loss.