Perugi G, et al. - Authors performed this observational study to assess internal (clinical-demographic, temperamental characteristics) and external (childhood trauma, psychosocial characteristics) factors potentially predicting remission at 12 weeks in bipolar-I patients experiencing manic episode and requiring to start or switch treatment with oral antipsychotics and/or mood stabilizers. Findings revealed that in most patients, treatment was associated with rapid improvements in symptoms and functioning after 12 weeks of initiation or change of oral therapy for mania in bipolar-I patients. None of the factors were observed to be associated with remission or demonstrated strong correlations with the improvements in clinical health state.