Jones CG, Rappold AG, Vargo J, et al. - In view of accelerating natural cycle of large‐scale wildfires that increasingly expose both rural and populous urban areas to wildfire emissions, researchers here examined cardiovascular effects linked with wildfire smoke. The relationship between out‐of‐hospital cardiac arrest and wildfire smoke density (light, medium, heavy smoke) from the National Oceanic Atmospheric Association's Hazard Mapping System was examined. The Cardiac Arrest Registry to Enhance Survival was referred for out‐of‐hospital cardiac arrest data for 14 California counties, 2015–2017 (N = 5,336). Analyses revealed increase in out‐of‐hospital cardiac arrest risk in correlation with wildfire smoke exposure; among those with lower socioeconomic status, the risk seemed higher. The future trajectory of wildfire, along with raising vulnerability of the aging population, highlights the significance of formulating public health and clinical strategies to protect those most vulnerable.