Gajic-Veljanoski O, et al. - Physicians designed this longitudinal analysis to investigate effects of modifiable and non-modifiable factors on changes in frailty in community-dwelling adults aged 50+ years who participated in the Canadian Multicentre Osteoporosis Study (CaMos). They showed that older adults with incident clinical vertebral fractures, hip fractures or obesity were at risk for more rapid progression of frailty. These individuals represented high-risk groups that ought to be considered for frailty interventions.