Nibell O, Svanstrom H, Inghammar M, et al. - Fluoroquinolone treatment was related to an elevated risk of acute liver injuries (ALI) in the first two months after initiating treatment in this propensity score matched study.

• The risk of ALI linked to oral fluoroquinolone treatment was compared with amoxicillin (419,930 courses propensity score matched 1:1) in this study.

• Compared with amoxicillin, users of oral fluoroquinolones had a more than 2-fold risk of ALI throughout a 60-day follow-up period.

• The adjusted absolute risk difference between fluoroquinolones and amoxicillin was 4.94 per 1 million episodes.