Arboleda LPA, et al. - Via retrospectively reviewing records for all cancer cases diagnosed from 1986 to 2016 affecting patients aged 19 years and younger, researchers discovered the relative frequency, demographic distribution and clinicopathological characteristics of pediatric oral and maxillofacial cancer (POMC). Through descriptive statistics, demographic variables, anatomical site, and histopathological diagnoses have been gathered and analyzed. Among 7,181 pediatric malignancies, 55 POMCs were found. White male patients were impacted more frequently. Lymphomas followed by sarcomas and carcinomas were the most common type of cancer. The most common histopathological diagnoses were Burkitt lymphoma, rhabdomyosarcoma, diffuse large B-cell lymphoma, and mucoepidermoid carcinoma. Oropharynx, followed by salivary glands, maxillofacial bone, and oral cavity was the main affected anatomical site. Findings suggested that POMC has a low incidence, but highly aggressive tumors are common in this scenario, such as lymphomas and sarcomas. Better knowledge of POMC's clinicopathological distribution can contribute to early diagnosis and improve rates of survival.