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Optimal donation of kidney transplants after controlled circulatory death

American Journal of Transplantation Feb 26, 2021

Savoye E, Legeai C, Branchereau J, et al. - For “extended criteria” donors with poorer kidney transplant outcomes, use of controlled donation after circulatory death (cDCD) is made. In 2015, initiation of the French cDCD program was done, which is characterized by normothermic regional perfusion, hypothermic machine perfusion, and short cold ischemia time. Researchers performed comparison of kidney transplantation outcomes from cDCD and brain‐dead (DBD) donors, matching cDCD and DBD kidney transplants by propensity scoring for donor and recipient characteristics. A total of 442 of 499 cDCD and 809 of 6,185 DBD transplantations were retained after the matching process. Both groups were similar with respect to the 1‐year graft survival rate. Kidney transplants from cDCD resulted in better early outcome than matched DBD transplants with this French protocol.

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