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Obstructive sleep apnea in refractory epilepsy: A pilot study investigating frequency, clinical features, and association with risk of sudden unexpected death in epilepsy

Epilepsia Sep 28, 2018

McCarter AR, et al. – Investigators conducted this pilot study to determine the frequency of probable obstructive sleep apnea (pOSA) in refractory epilepsy monitoring unit in patients and clinical features related to pOSA, including risk for sudden unexpected death in epilepsy (SUDEP). They prospectively enrolled 49 consecutive adults admitted to the Mayo Clinic Epilepsy Monitoring Unit with focal, generalized, or unclassified epilepsy syndromes. Of these patients, 35% had pOSA. Researchers identified a high frequency of pOSA in refractory epilepsy monitoring patients. Findings suggested that patients with pOSA were older and heavier, and more frequently had a focal epilepsy syndrome and longer epilepsy duration. The investigators also noted a possible association of OSA with SUDEP risk. In patients with epilepsy, identification and treatment of OSA could serve as a novel approach for SUDEP risk prevention.

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