Lai SH, et al. - The association between body mass index (BMI), homocysteine level and impaired renal function was examined in a Taiwanese adult population. Increased risk of chronic kidney disease (CKD) was observed in overweight/obese patients with higher homocysteine levels. This was particularly observed in females. Additional studies were required to investigate whether the effect of weight loss or homocysteine-lowering therapies like folic acid, vitamin B₁₂ supplements that could prevent or slow the progression of declining renal function.