Herrspiegel C, Kvanta A, Lardner E, et al. - This study was sought to assess whether transvitreal incisional biopsies enable histological examination as well as immunohistochemical staining of BRCA1-associated protein-1 (BAP-1). Between 2003 and 2019, researchers recruited a total of 59 patients who diagnosed with choroidal melanoma in transvitreal biopsies. Twenty-one of these patients subsequently had undergone enucleation. Furthermore, the level of nuclear expression of BAP-1 in transvitreal biopsies and enucleations was analyzed and the concordance estimated. For metastasis, metastasis-free survival and HR were examined. In this study, loss of nuclear BAP-1 expression happened in a large proportion of the small tumours. This study's findings demonstrate that BAP-1 immunoreactivity in transvitreal incisional biopsies of choroidal melanoma is substantially concordant with immunoreactivity in enucleated specimens and distinguishes individuals with poor metastasis-free survival.