Feld L, Fiorino EK, Aygun B, et al. - Whether patients with sickle cell disease (SCD) would have raised N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) levels vs age‐adjusted healthy children, was investigated. Also, if these levels would be related to labs suggestive of hemolysis and would show evidence of obstructive lung disease and cardiac dysfunction, was determined. A retrospective analysis of patients with SCD, 8–18 years old, was performed. A median NT‐proBNP of 70 pg/ml was detected in the age group 8–14 years old (75% of the cohort's population), which was greater compared with their age‐adjusted counterparts (52 pg/ml). An increased degree of hemolysis was detected in relation to NT‐proBNP levels vs hemoglobin, reticulocyte count and lactate dehydrogenase levels. There was an inverse trend between NT‐proBNP and spirometric data. NT‐proBNP was positively correlated with diastolic left ventricular size. Based on the observed correlations, experts inferred that NT‐proBNP may be employed prospectively to detect SCD cases at elevated risk for the occurrence of cardiopulmonary dysfunction.