Bosch LJW, et al. - The purpose of this research was to determine novel protein biomarkers in stool that outperform or complement hemoglobin in detecting colorectal cancer (CRC) and advanced adenomas. The novel candidate protein biomarkers for CRC screening were detected via mass spectrometry of stool samples. It was discovered that several protein combinations outperformed hemoglobin in discriminating CRC or advanced adenoma from control samples. Proof of concept that such proteins could be detected with antibody-based assays in small sample volumes pointed towards the ability of these biomarkers to be applied in population screening.