Boxberg M, et al. - Because researchers have recently proposed a novel (three-tiered) clinically useful grading scheme strongly related to squamous cell carcinoma of the oral cavity (OSCC) patient outcome, consisting of a sum score of tumor budding histomorphological patterns and cell nest size that outperforms current WHO based grading algorithms, they tested the reliability of this novel grading system for interobserver and intraobserver. According to the proposed grading scheme, 108 OSCC were retrospectively scored. According to results, intraobserver concordance was high, showing a high algorithm reproducibility. Overall, the investigators suggested that the grading of OSCC based on the proposed novel scheme results in an excellent inter-reader and intrareader agreement, further supporting the suitability of this grading system for routine pathological practice.