Lytvynchuk LM, Petrovski G, Dam A, et al. - In the present study, the researchers sought to examine the effectiveness of a novel needle for intravitreal injection (IVI) in comparison to the conventional needle under experimental conditions. The newly designed 30-gauge (G) needle (NDN) (EP 18158 542.3, patent pending) with occluded outer orifice and a side port for drug delivery was contrasted to the conventional standard hypodermic 30 G needle for IVI (SHN). With regard to a significantly reduced number of cells being captured by the needle tip, the NDN showed superior results. Delivery of the injected fluid into the vitreous cavity was similar. Further studies with improved prototypes would be needed to investigate the superior properties of the NDN needle design.