Dai Z, Wang Y, Wu Z, et al. - A case-control study was carried out to evaluate the relationship of urotensin II (UTS2) signals with the susceptibility of adolescent idiopathic scoliosis (AIS) in the Chinese Han population. Researchers conducted gene expression analysis in 36 AIS patients and 36 age-matched congenital scoliosis patients. The genotyping data between the groups were compared by using the Chi-square test. Using the Student t-test, gene expression analysis was compared. There was a significant association between rare mutations in UTS2R and AIS. In AIS patients, the expression of UTS2R was significantly elevated. The role of UTS2 signaling in the development of AIS is worthy of future evaluation.