Kamshilin AA, et al. - In this experiment performed on 14 migraine patients (mean age 34.6 ± 10.2 years) and 14 healthy volunteers (mean age 29.9 ± 9.7 years), researchers used a new arrangement of imaging photoplethysmography recently developed to discover novel sensitive parameters of dermal blood flow during capsaicin applications in migraine patients. Findings suggest blood pulsation amplitude (BPA) dynamics measured by imaging photoplethysmography could potentially serve as a novel sensitive non-invasive biomarker of migraine-associated changes in microcirculation.