Maloca PM, et al. - Researchers evaluate geometric indices (vessel sphericity and cylindricity) for volume-rendered optical coherence tomography angiography (OCTA) in 26 eyes of 13 healthy individuals and 12 eyes of patients with central ischemic, non-proliferative diabetic retinopathy. In healthy eyes and the diabetic eyes, average OCTA volume was 0.49 ± 0.09 mm³ vs 0.44 ± 0.07 mm³ (SD), respectively (difference in means 0.06 mm³) and the overall average OCTA surface area was 87.731 ± 9.51 mm² (SD) vs 76.65 ± 13.67 mm² (SD), respectively (difference in means 11.08 mm²). The proportion of blood vessels in relation to total foveolar tissue volume was 22% in healthy individuals and only 20% in diabetics. The groups exhibited a more pronounced difference with respect to the total OCTA surface area, with a decrease of 13% in diabetics. A diabetic eye was most likely using geometric vessel indices analysis if the sphericity value was ≥ 0.190, with a cylindricity factor of ≥ 0.001. The method for OCTA surface area and volume measurements had good reproducibility. To characterize a stable disease or disease progression, possible suitability of the application of the novel OCTA sphericity and cylindricity indices as temporal biomarker was suggested and these may contribute to a better understanding in the evolution of diabetic retinopathy.