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Normal liver stiffness and influencing factors in healthy children: An individual participant data meta‐analysis

Liver International Nov 03, 2020

Li DK, Khan MR, Wang Z, et al. - Researchers conducted a systematic review and individual participant data (IPD) meta‐analysis to determine the range of liver stiffness in healthy children and assess the influence of important biological parameters. Data were pooled from 10 studies that investigated healthy children using transient elastography (TE). Six hundred fifty-two children were analyzed after excluding children with obesity, diabetes, or abnormal liver tests. TE‐derived liver stiffness ranges have been developed for healthy children and the upper limit of liver stiffness in healthy children is suggested to be 5.56 kPa. Increased age, use of sedation, probe size, and presence of steatosis on ultrasound have been reported as factors that can significantly increase liver stiffness.

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