Remes‐Troche JM, Taboada‐Liceaga H, Gill S, et al. - In this study, the dose-response effect of extracted nopal fiber powder on symptoms in irritable bowel syndrome (IBS) was explored. A 4‐arm, double‐blind, parallel, randomized controlled trial was conducted including a total of 60 patients fulfilling Rome IV criteria for IBS. Individuals were assigned randomly to receive either nopal fiber (10, 20, or 30 g/day) or placebo (30 g/day dextrose) for one week and to keep their usual diet. Researchers assessed symptom severity (Global Symptom Question, IBS‐SSS, Gastrointestinal Symptom Rating Scale), stool frequency and consistency (Bristol Stool Form Scale), breath hydrogen response, and stool short‐chain fatty acids at baseline and follow‐up. It was shown that in IBS symptoms, nopal fiber supplementation at doses of 20 and 30 g/day was correlated with short‐term improvement, required a fully-powered clinical trial of longer duration with symptomatic, physiological, and microbiological endpoints.