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Nonalcoholic fatty liver disease is associated with arterial distensibility and carotid intima-media thickness: (from the Multi-Ethnic Study of Atherosclerosis)

The American Journal of Cardiology Aug 01, 2019

Oni E, Budoff MJ, Zeb I, et al. - Researchers examined the link between nonalcoholic fatty liver disease (NAFLD) and subclinical cardiovascular disease (CVD) markers (ie, common and internal carotid intima-media thickness [CIMT] and coronary artery calcium > 0) among 4,123 participants without previous CVD from the Multi-Ethnic Study of Atherosclerosis, after excluding 2,692 adults. The study sample was 55% female, 39% white, 10% Chinese, 28% black, and 23% Hispanic. The NAFLD prevalence was 17% (n = 729). Higher distensibility coefficient and higher CIMT were observed in patients with NAFLD. Presence of NAFLD was linked with both the common carotid and internal carotid IMT and logCAC in multivariate linear regression analysis. The link with CIMT > 1 mm was significant in whites and Hispanic and CAC > 0 was significant in Hispanics when stratified by race. In a multiethnic population, findings revealed a modest association of NAFLD with carotid IMT and coronary artery calcification.

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