Chen X, Guo F, Hoffmeister M, et al. - Because regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been linked to a lower risk of colorectal cancer (CRC), researchers conducted this large-scale case-control study to see if this link varies according to background polygenic risk for CRC. Data were obtained from a large population-based case-control study on CRC in Germany. Using multivariable logistic regression, the associations between regular use of NSAIDs (≥ 2times per week for at least 1 year) and CRC risk were estimated in the whole population and in subgroups based on polygenic risk score (PRS) levels. This study included 5,129 CRC cases and 4,093 controls. Regular use of NSAIDs is associated with a significantly lower risk of CRC, regardless of individual genetic profile. Absolute risk reduction would be expected to be greatest among those with the highest PRS, with an equivalent reduction in relative risk across all polygenic risk groups.