Boesgaard Graversen C, Brink Valentin J, Lytken Larsen M, et al. - Among patients with incident acute coronary syndrome (ACS), some of the income-related inequality in risk of major adverse cardiovascular events (MACE) (including all-cause death, cardiac death and cardiac readmission) was shown to be mediated by non-persistence with medication, in men but not women.

• In cases with incident ACS, a higher risk of MACE exists in relation to low socioeconomic status.

• Participants were 45,874 Danish patients with incident ACS; 16,958 (37.0%) were non-persistent with medication.

• High income, vs low income, was associated with lowering of adjusted hazard ratio of MACE by 33% (hazard ratios HR: 0.67) in men and by 34% (HR: 0.66) in women.

• Based on education level, similar findings were acquired.

• There was a socioeconomic disparity in risk of non-persistence among men but not women and only in relation to income.

• High-income men exhibited a lower risk of non-persistence which mediated the lower risk of MACE by 12.6% than low-income men.