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Non-alcoholic fatty liver disease is associated with arterial distensibility and carotid intima media thickness: (from the Multi-Ethnic Study of Atherosclerosis [MESA])

The American Journal of Cardiology May 31, 2019

Oni E, et al. - Researchers assessed the association of non-alcoholic fatty liver disease (NAFLD) with subclinical cardiovascular disease (CVD) markers (common and internal carotid intima media thickness [IMT] and coronary artery calcium > 0), given that NAFLD is considered a potential independent risk factor for CVD. Participants were 6,814 adults without prior cardiovascular disease enrolled in the Multi-Ethnic Study of Atherosclerosis cohort. Cases with missing variables, heavy drinkers, or participants with a history of steroid use and/or chronic liver disease were excluded (n=2,692). Ultimately, they included 4,123 participants with the following ethnic proportions: 39% white, 10% Chinese, 28% black, and 23% Hispanics. In this study of a multi-ethnic population, a modest association of NAFLD with carotid IMT and coronary artery calcification was evident.

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