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Nomogram predict relapse-free survival of patients with thymic epithelial tumors after surgery

BMC Cancer Jul 28, 2021

Huang YY, Wu LL, Liu X, et al. - Given a crucial role of hematological indicators and clinical characteristics in the assessment of the progression as well as prognosis of thymic epithelial tumors, researchers sought to integrate these potential indicators to develop a prognostic nomogram to ascertain the relapse-free survival (RFS) of patients suffering from thymic epithelial tumors receiving thymectomy. They conducted a retrospective analysis of 156 patients who had thymectomy between May 2004 and August 2015. They constructed a nomogram incorporating preoperative albumin levels, neutrophil-to-lymphocyte ratio, T stage, and WHO histologic types. Good prognostic ability (C index: 0.902) of the nomogram was noted in the training cohort. For the RFS, calibration curves were found to be in good agreement with the standard lines in training and validation cohorts. Overall, the nomogram, by combining clinical and hematologic factors, showed a good performance in predicting the prognosis as well as the relapse-free survival of this patient population. Additionally, high-risk patients can potentially be detected at an early stage with the help of this nomogram. This represents a relatively novel strategy for the prediction of RFS in this patient population.

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