Lajaunie R, Cuzin L, Palich R, et al. - Researchers examined if among patients living with HIV (PLHIV) with history of Kaposi Sarcoma (KS) and controlled HIV replication, the risk of KS relapse increases in correlation with switching from a protease inhibitors (PI)-based regimen to a PI-free one.

• The prospectively collected Dat’AIDS database was retrospectively analyzed to obtain data of patients who both had a past KS history and a HIV-1 viral load below 200 copies/mL while being PI-treated.

• There were 216 patients with past KS events and a history of HIV-1 infection efficiently treated by a PI-based regimen.

• Of these, 148 patients (68.5%) switched to a PI-sparing regimen in a later course of treatment.

• KS relapses were reported in 3.2% of the individuals in this cohort of PLHIV.

• Switching of a PI-containing ART regimen to a PI-free regimen did not link with increased frequency of the relapses.

• Overall, there appeared no specific effect of PI on KS.