Dathe K, et al. - In this analysis, researchers focused on ibuprofen exposure pattern during 1st trimester and compared 1,117 women exposed to ibuprofen in the 1st trimester to 2,229 non-exposed women. Findings suggested no significant increase in the risk of major birth defects or a distinct pattern of birth defects. Subgroup analyses of pregnancies exposed for ≥7 (n = 223) and ≥30 days (n = 72) indicated no higher risk with increasing treatment duration, thereby suggesting that ibuprofen does not carry a substantial embryotoxic risk.