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New nonalcoholic fatty liver disease and fibrosis progression associate with the risk of incident chronic kidney disease

Journal of Clinical Endocrinology and Metabolism Jun 18, 2021

Zuo G, Xuan L, Xin Z, et al. - This community-based prospective study was performed to evaluate the relations of nonalcoholic fatty liver disease (NAFLD) status changes and NAFLD fibrosis progression with the risk of incident chronic kidney disease (CKD) among individuals aged 40 years or older and free of CKD at baseline in 2010, and followed up after a mean of 4.4 years. Using ultrasonography, a diagnosis of NAFLD was made. Assessment of fibrosis stage and progression was performed using NAFLD fibrosis score. CKD was characterized by estimated glomerular filtration rate or urine albumin-to-creatinine ratio. Findings showed an elevated risk of incident CKD in relation to both NAFLD development and fibrosis progression.

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