Ferreira I, et al. – The current study was interested in exploring the use of solvents that are not traditionally used in dentistry for the dissolution of an epoxy resin–based sealer and the effect of ultrasonic agitation (UA). It was found that methyl ethyl ketone [MEK] and ethyl acetate proved to be excellent alternatives to chloroform or xylene solvents. In addition, MEK presented a high sealer dissolving ability in a short period, particularly with UA, without the potential hazards of chloroform, proposing it is a good approach to AH Plus sealer's dissolution empowered by UA.