Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in discriminating precancerous pathologies from cervical cancer
Journal of Oncology Oct 01, 2019
Tas M, et al. - Researchers examined whether hematological markers of inflammation hold value in predicting the presence/absence of cervical cancer (CC). Whether these markers can distinguish precancerous cervical pathologies from CC, was also determined. Retrospectively included 40 patients with low-grade squamous intraepithelial lesions, 40 with high-grade squamous intraepithelial lesions, and 30 with CC were examined, along with 70 healthy volunteers with normal cervical cytology (control group). The presence of CC was predicted by age, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), as revealed in logistic regression analysis. NLR, at a cutoff value of 2.02, displayed 71% sensitivity and 60% specificity (AUC: 0.682) for predicting CC, and PLR showed 83% sensitivity and 69% specificity (AUC: 0.752) at a cutoff value of 126.7 for CC prediction, in ROC curve analysis. Overall, experts concluded that the evaluation of NLR and PLR values, in addition to patients’ age, may aid in decision making precancerous pathologies of the cervix.
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