Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in discriminating precancerous pathologies from cervical cancer
Journal of Oncology Sep 05, 2019
Tas M, et al. - In this analysis of retrospectively included patients with low-grade squamous intraepithelial lesions (n = 40), high-grade squamous intraepithelial lesions (n = 40), and those with cervical cancer (CC; n = 30), researchers assessed the predictive value of various hematological markers of inflammation on the presence/absence of cervical cancer. They also investigated their efficacy in distinguishing precancerous cervical pathologies from cervical cancer. The presence of CC was predicted by age, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), in logistic regression analysis. In ROC curve analysis, CC was predicted by NLR and PLR, with the respective cutoff value of 2.02 (71% sensitivity and 60% specificity, AUC: 0.682) and 126.7 (83% sensitivity and 69% specificity, AUC: 0.752) for NLR and PLR. Overall, the decision making for precancerous pathologies of the cervix may be assisted by assessing NLR and PLR values, which represent simple, inexpensive, and easily accessible markers of systemic inflammation, in addition to patients’ age.
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