Luescher T, et al. - Researchers examined if the prognostic ability of two cardiac arrest specific risk scores could be enhanced by measuring neuron-specific enolase (NSE) at different days after a cardiac arrest. In this prospective observational study, 336 consecutive adult patients were assessed after cardiac arrest for the out-of-hospital cardiac arrest score and the Cardiac Arrest Hospital Prognosis score upon ICU admission. Serum NSE was measured upon admission and days 1, 2, 3, 5 and 7. Survival until hospital discharge was reported in 54% patients, and 45% had a good neurological outcome. The analysis revealed significant improvement in clinical risk scores for outcome prediction in cardiac arrest patients when measuring NSE at day 3; they recommend adding NSE measurement at day 3 to clinical decision making about escalation or withdrawal of therapy in this vulnerable patient population.