Duez CHV, et al. - The impact of prolonged targeted temperature management (TTM) in cardiac arrest patients on release of serum levels of NSE and S-100b and their prognostic performances were assessed. Researchers identified no clinically significant differences in the levels of NSE or S-100b between standard and prolonged TTM. The biomarkers NSE and S-100b remained reliable prognosticators, even in the case of prolonged TTM after cardiac arrest.