• Profile

Neuroinflammation as potential precursor of leukoencephalopathy in early-stage breast cancer patients: A cross-sectional PET-MRI study

The Breast Feb 04, 2022

In this multimodal neuroimaging study, observations indicate the likely involvement of neuroinflammatory processes in the development of juxtacortical, but not periventricular or deep white matter, leukoencephalopathy shortly following chemotherapy for early-stage breast cancer.

  • This study included 15 chemotherapy-treated and 15 age-matched chemotherapy-naïve patients with early-stage breast cancer, as well as 15 healthy controls, to investigate the presence of leukoencephalopathy after multiagent chemotherapy in women treated for breast cancer and potential underlying neuroinflammatory processes.

  • Total or localized lesion burden did not differ significantly between groups.

  • Significantly higher (20–45%) translocator protein uptake was noted in juxtacortical lesions vs normal appearing white matter in both cancer groups, but only persisted for chemotherapy-treated patients post-partial volume correction.

  • There was no association of neurofilament light-chain serum levels with total lesion volume or tracer uptake in juxtacortical lesions.

Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
M3 app logo
Choose easy access to M3 India from your mobile!

M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen