Neuroinflammation as potential precursor of leukoencephalopathy in early-stage breast cancer patients: A cross-sectional PET-MRI study
The Breast Feb 04, 2022
In this multimodal neuroimaging study, observations indicate the likely involvement of neuroinflammatory processes in the development of juxtacortical, but not periventricular or deep white matter, leukoencephalopathy shortly following chemotherapy for early-stage breast cancer.
This study included 15 chemotherapy-treated and 15 age-matched chemotherapy-naïve patients with early-stage breast cancer, as well as 15 healthy controls, to investigate the presence of leukoencephalopathy after multiagent chemotherapy in women treated for breast cancer and potential underlying neuroinflammatory processes.
Total or localized lesion burden did not differ significantly between groups.
Significantly higher (20–45%) translocator protein uptake was noted in juxtacortical lesions vs normal appearing white matter in both cancer groups, but only persisted for chemotherapy-treated patients post-partial volume correction.
There was no association of neurofilament light-chain serum levels with total lesion volume or tracer uptake in juxtacortical lesions.
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