Sert S, et al. - While the regulatory impacts on periodontal inflammatory responses of substance-P (SP), neurokinin-A (NKA), calcitonin gene-linked peptide (CGRP) and neuropeptide-Y (NPY) were outlined, researchers intended to describe the impacts of these neuropeptides on healthy and diseased peri-implant tissues. Using a a split-mouth study design, they assessed and compared 39 implants loaded at least for 12 months with their symmetrically matching teeth. Depending on the periodontal status, neuropeptide levels in the teeth and implant groups were different. The levels of SP and NKA were risen, while the levels of CGRP and NPY in the diseased states were reduced. No differences were found between the neuropeptide levels of matching teeth and implants. The outcomes showed that local neuropeptides are present in healthy and diseased peri-implant tissues. In both peri-implant and periodontal tissues, the neurogenic inflammatory responses have also been found to be similar.