Klimes-Dougan B, et al. - Researchers undertook this pilot study to assess the biological predictors of response to antidepressant treatment in adolescents with depression. In this study, lower amygdala connectivity with left supplementary motor area and with right precentral gyrus, and greater amygdala connectivity with right central opercular cortex and Heschl's gyrus connectivity during rest were identified as the neural predictors of favorable treatment response. Neural predictors of treatment response during an emotion task were greater activation of the bilateral anterior cingulate cortex and left medial frontal gyrus. Furthermore, an association of different patterns of salivary cortisol obtained in the context of a modified Trier Social Stress Test with those whose depressive symptoms remitted as compared to those whose symptoms persisted was observed. Findings demonstrated significant promise for identifying predictors of treatment response in adolescents with depression.