Schierbeck S, Nord A, Svensson L, et al. - In out-of-hospital-cardiac-arrest (OHCA), early defibrillation is essential for enhancing the chance of survival. Given the substantial potential of automated external defibrillator (AED)-equipped drones to shorten times to defibrillation in OHCA patients, researchers sought to determine areas of high incidence of OHCA on a national level for placement of AED-drones, as well as to estimated the number of drones required to reach 50%, 80%, 90% and 100% of the target population within 8 minutes. Via performing a retrospective observational study of OHCAs reported to the Swedish Registry for Cardiopulmonary Resuscitation between 2010–2018, they included 39,246 OHCAs. Per estimates, 61 drone systems would be required to reach all OHCAs in high-incidence areas with AEDs delivered by drone or ambulance within 8 minutes leading to an overall OHCA coverage of 58.2%, and median timesaving of 05:01 (min:sec). Twenty-one drone systems would be required to reach 50% of the historically reported OHCAs in < 8 min; 366 for 80%, 784 for 90%, and 2,408 for 100%. Overall findings suggest that high incidence areas of OHCA can be identified at a national level via performing geographical information system-analyses and their utility as tools to quantify the need of AED-equipped drones. National coverage of OHCA can be substantially increased by using only a small number of drone systems.