Schiavi L, Brindisi G, Castro GD, et al. - Researchers performed this monocentric, prospective, observational study to evaluate the change in nasal reactivity after grass-pollen allergen immunotherapy (AIT) treatment. This investigation was carried out in Rome from September 2016 to June 2018, in the Pediatric Department of Policlinico Umberto I. Children, ages between 6 and 12 years, with persistent allergic rhinitis (AR), sensitized to grass pollen were recruited. Patients engaged in two follow-up visits, in May 2017 (V1) and May 2018 (V2), with the same examinations as at V0. In the treated group, the authors found a significant increase in the mean nasal flow compared with untreated children during the treatment. They observed an improvement of nasal function in the AIT group and only 21.05% of all the children in the active group with a positive nasal provocation test result at V2. In the control group, they observed a deterioration of nasal function at V2, with 89.47% of the children reporting a positive NPT result. They also discovered a significant decline of nasal specific IgE levels at the end of the observation period in the treated group. Data analysis gave evidence of a clinical effect of SLIT in inducing clinical changes and tolerance to allergens in children with AR.