Ning J, et al. - In this systematic review and meta-analysis of seven studies comprising of 10,650 persons who underwent nasal swab examination prior to spine surgeries, experts assessed the impacts of nasal colonization of Staphylococcus aureus (SA), methicillin-susceptible SA (MSSA), and methicillin-resistant SA (MRSA) on the incidence of surgical site infection (SSI) following spine surgery. During follow-up, a total of 244 SSI events transpired, including 57 MRSA-SSI events. Pooled results explicated that the risk of overall SSI following surgeries nasal SA or MSSA was not significantly influenced by colonization. Nevertheless, nasal MRSA colonization was related to significantly heightened risks of overall SSI and MRSA-SSI. In studies without MRSA decolonization, the relationships between nasal MRSA colonization and heightened risks of overall and MRSA-SSI remained meaningful, however, it became unimportant in studies with MRSA decolonization. Hence, nasal MRSA colonization could be related to heightened risks of overall SSI and MRSA-SSI following spine surgeries, and nasal MRSA decolonization may be related to a decrease of SSI in these persons.