Carpenter J, et al. - Given a correlation of illicitly manufactured fentanyl (IMF) with a growing number of deaths and that IMF overdoses may need significantly higher naloxone doses than heroin overdoses, researchers examined the association of the naloxone dose required to treat an opioid overdose with the finding of fentanyl, opiates, or both on urine drug screen (UDS). They retrospectively reviewed 837 charts for this work and included 121 individuals (median age: 38 years; 75% males) in the final analysis. Findings did not support the notion that high potency synthetic opioids like illicitly manufactured fentanyl require heightened doses of naloxone to successfully treat an overdose. No significant discrepancies were observed in the dose of naloxone needed to manage opioid overdose patients with UDS evidence of exposure to fentanyl, opiates, or both.