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Multiple factors predict longer and shorter time-to-ulcer-free in people with diabetes-related foot ulcers: Survival analyses of a large prospective cohort followed-up for 24-months

Diabetes Research and Clinical Practice Feb 08, 2022

Researchers aimed at determining the factors that are independently linked with time-to-(being)-ulcer-free, time-varying effects and predict adjusted ulcer-free probabilities, in a large prospective cohort with diabetes-related foot ulcers (DFU) followed-up for 24 months.

  • From 65 Diabetic Foot Services across Queensland, Australia, researchers included 4,709 patients (median age 63 years, 69.5% male).

  • Median time-to-(being)-ulcer-free was 112 days and within 2 years, there were 68.4% patients who were ulcer-free.

  • There was an independent correlation of each year younger than 60 years with longer time-to-ulcer-free.

  • Longer time-to-ulcer-free, but only for 6 months was observed, in correlation with peripheral artery disease (PAD) and ulcer size.

  • Shorter time-to-ulcer-free was observed in correlation with podiatry and knee-high offloading treatment.

  • There appeared the largest probability of being ulcer-free for geographical remoteness and PAD factors.

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