Harvin JA, Albarado R, Truong VTT, et al. - Researchers conducted an unblinded, pragmatic, randomized, comparative effectiveness trial with the aim to compare two multimodal pain regimens (MMPR) with the goal of reducing opioid exposure and annihilating acute pain in a busy, urban trauma center. Comparison was performed between the original MMPR (intravenous administration, followed by oral, acetaminophen, 48 hours of celecoxib and pregabalin followed by naproxen and gabapentin, scheduled tramadol, and as needed oxycodone) and a MMPR with generic medications, termed the MAST MMPR (oral acetaminophen, naproxen, gabapentin, lidocaine patches, and as needed opioids). They randomized 1,561 patients, with 787 going to the original MMPR and 774 going to the MAST MMPR. Per outcomes, the MAST MMPR was a generalizable and widely available approach that aided in lowering opioid exposure following trauma and allowed achievement of adequate acute pain control. Patients randomized to the MAST MMPR had lower morphine milligram equivalents per day and fewer were prescribed opioids at discharge (62% vs 67%).