Mortality risk prediction in amyopathic dermatomyositis associated with interstitial lung disease
Chest Jul 15, 2020
Lian X, Zou J, Guo Q, et al. - Given that amyopathic dermatomyositis (ADM)-associated interstitial lung disease (ILD) carries a poor prognosis, and there is a necessity for a mortality risk score model for predicting survival in patients with ADM-ILD as well as to guide clinical treatment, so, researchers sought to identify patients suffering from ADM-ILD who carry a high risk as well as to predict patient result based on a risk stratification model. This prospective inception study involved 207 patients with ADM-ILD. A combined risk score, the FLAIR score, was built and using this score, patients were split into three risk groups: low, 0 to 4; medium, 5 to 9; and high, 10 to 13. Significantly higher death rates were observed in high-risk patients vs low- and medium-risk patients, in both discovery and validation cohorts. Overall, experts suggested the usefulness of the FLAIR risk score model in predicting survival in patients with ADM-ILD as well as in guiding further clinical research on risk-based treatment.
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