Choi HG, et al. - A total of 1,125,691 individuals registered over a 12-year period in a national insurance database were recruited in order to examine the mortality rates and reasons of death in patients with Parkinson disease (PD, second most prevalent neurodegenerative disorder, and is described by the four cardinal motor signs, ie, tremor at rest, bradykinesia, rigidity and postural instability, as well as other non-motor clinical manifestations) using a representative PD population in South Korea, to better understand the natural courses and prognoses of patients with PD, and to give important information on planning the distribution of health resources. Although, the data still exhibited that irrespective of modern advances in the treatment of this disease, the mortality of patients with PD was greater than that in control populations. This indicates that, while current treatment modalities alleviate motor symptoms, they do not significantly enhance mortality rates and/or the life expectancies of patients with PD. Thus, irrespective of age and gender, PD raised the risk of mortality. In patients with PD, prevalent causes of death incorporated metabolic, mental, neurologic, circulatory, respiratory and genitourinary diseases as well as trauma and the highest OR recognized was for neurologic disease. It is the largest study of its type to date.