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Mortality and cardiovascular events in adults with kidney failure after major non-cardiac surgery: A population-based cohort study

BMC Nephrology Nov 10, 2021

Harrison TG, Ronksley PE, James MT, et al. - Via examining major non-cardiac surgery for people with kidney failure, both with and without dialysis, researchers investigated the proportion of people experiencing acute myocardial infarction (AMI) or death within 30 days of the surgery, based on surgery type.

  • A retrospective population-based cohort study of 3,398 adults with major surgery that had preoperative estimated glomerular filtration rates (eGFRs) < 15 mL/min/1.73 m2 or received chronic dialysis.

  • An AMI or death occurred within 30 days of surgery in 272 people (8.0%).

  • Observations revealed significant influence of surgery type on the risk of death or AMI after major non-cardiac surgery among people with kidney failure.

  • The most frequent procedure recorded was kidney transplantation which was linked with one of the lowest estimated probabilities of this outcome.

  • Higher proportions were recorded following head and neck, thoracic, vascular, skin and soft tissue, intra-abdominal, musculoskeletal, retroperitoneal, anorectal, and neurosurgical procedures.

  • Urgent or emergent major surgery linked with the highest risk.

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