Kim I, et al. - In the present study, the researchers sought to examine the structure of multilayered pigment epithelial detachment (m-PED) in neovascular age-related macular degeneration, and its correlation with visual prognosis and the progression of fibrotic scars at 12 months. A total of 68 eyes from 63 patients with m-PED and a prechoroidal cleft were examined retrospectively. The compartments within m-PED were divided into three layers: neovascular tissue (layer 1), a hyper-reflective band (layer 2), and a prechoroidal cleft (layer 3). The m-PED with layer 2 had a higher risk of fibrotic scar formation and was linked to a poor visual prognosis. Layer 2 may be a precursor to a fibrotic scar in its early stages.