Kajubi R, et al. - Given that intermittent treatment with sulfadoxine-pyrimethamine, recommended for prevention of malaria in pregnant women across sub-Saharan Africa, is threatened by parasite resistance, researchers tested the safety and effectiveness of intermittent preventive treatment with dihydroartemisinin-piperaquine as an alternative to sulfadoxine-pyrimethamine. This investigation was performed at one rural site in Uganda with high malaria transmission and sulfadoxine-pyrimethamine resistance. For this double-blind, randomised, controlled, superiority trial, 782 women were enlisted and randomly assigned to receive sulfadoxine-pyrimethamine (n=391) or dihydroartemisinin-piperaquine (n=391) between September 6, 2016, and May 29, 2017. The primary analysis included 666 (85·2%) women who delivered live births. Based on the findings, the investigators concluded that monthly intermittent preventive treatment with dihydroartemisinin-piperaquine was safe, but compared with sulfadoxine-pyrimethamine did not result in significant improvements in birth outcomes.