Gelfond J, et al. - Experts evaluated the modifiable factors contributing to renal cell carcinoma in the PLCO trial to target disease prevention and reduce health care costs. They queried the prostate, lung, colorectal, and ovarian database for the primary outcome of kidney cancer. They gauged the demographics with a specific focus on modifiable risk factors. To reduce renal cell carcinoma, the 3 modifiable risk factors that could aggressively be targeted were obesity, hypertension, and smoking.